What is Angiogenesis And How Can it Help Me Fight Cancer

Angiogenesis is the formation of new blood vessels in the human body that support the growth and development of new body cells. It is an essential part of healing when someone suffers a wound or an injury as well as an important function for a benign tumour to become a malignant one which then becomes life threatening. Research today has been focusing on ways to stop angiogenesis and thus control the growth and development of all cancer cells.

Scientists since the 1970’s have been aware of the importance of angiogenesis in controlling cancer growths and have been searching for ways to stop these new blood vessels forming. To date they have had limited success. When cancer cells first develop they are supplied with nutrients from nearby blood vessels but to grow larger than 1 to 2 millimetres they need their own blood vessels. New blood vessels then have to grow which will feed the new cancer cells and allow them to increase in size. That is an absolute requirement.

One of the latest drugs to inhibit angiogenesis is Avastin which is extremely expensive, has serious side effects but has not had the results they had hoped for. Another drug also in use today for cancer is one that caused huge problems during the late 60s. It is Thalidomide which back then was given to women suffering from morning sickness during pregnancy but one of the side effects was angiogenesis. It stopping the formation of new blood vessels and thousands of children were born without limbs.

Researches for cancer today are looking for a drug that will stop cancer from growing, without side effects and also is harmless to normal body cells. While there are a couple of drugs that have some ability to do just that, what we are not told is that we already have many natural products that have the same result and without any side effects. These natural products are of course some of our natural food that has been grown and produced by nature.

The many products that nature has supplied us with and are angiogenesis inhibitors are;

* Food that is high in vitamin A, C and E. Some examples for vitamin A are carrots and sweet potatoes, vitamin C, strawberries and citrus fruit, and vitamin E, almonds and broccoli. * Bromeliad which is found in fresh pineapple. * Mistletoe which is also known as Iscador, and is also well known to boost the immune system. * Green tea which is one of Mother Natures wonders. * Milk-Thistle, also known as Silymarin, this herb is known for its liver protection effect. * Artemisia Annua also called sweet wormwood and has also been helpful for people with malaria. * Omega 3 Fatty Acid which is used in the popular Joanna Budwig diet and is found in flaxseed oil and salmon. * Mushrooms, especially the varieties reiski and maitake. * Resveratrol which is found on the skin of red grapes and also in red wine. * Quercetin; is in apples, onions, red grapes, citrus, cherries, broccoli and leafy green vegetables and it inhibits angiogenesis.

Many of the foods listed above not only do they inhibit blood vessels forming but many of them are also known as cancer fighting foods. One of the best foods a patient can eat is food from the cruciferous family which is broccoli, cauliflower, cabbage and brussel sprouts.

We are all part of nature so therefore to fight cancer successfully we must turn to nature to solve the problem. Nature has always had the answers to cancer whereas man does not.

Alan Wighton is an experienced natural therapist specializing in nutrition. If you are seeking information on how to fight cancer, using simple changes with diet and lifestyle, visit his website and learn how the body can fight cancer when you make these changes; www.cancerhealed.com http://www.cancerhealed.com

Esophageal Cancer Symptoms And Natural Remedies

The long tube like structure connecting the stomach and the mouth is called the esophagus which can get affected by cancer and is called as esophageal cancer. In adults, the esophagus is ten inches in length and is normally a hollow structure. Esophageal cancer can also be called as cancer of the esophagus. Normally esophageal cancer is only diagnosed after the disease has advanced so that it becomes difficult to treat the patients suffering from it. The treatment options become very limited when the disease has progressed. Hence it is very important to note the symptoms and signs of esophageal cancer and get treated as soon as possible.

Esophageal cancer might be seen commonly among heavy smokers, drunkards, in males than in females and mostly above sixty years of age. The treatment for the above condition might depend on the location of the problem, size of the problem and the stage of the problem in a patient.

Normally they are classified as adenocarcinoma and squamous cell esophageal cancer. Adenocarcinoma normally occurs near or at the stomach and esophagus junction called as the GE junction or Gastro esophageal junction and the sqaumous cell esophageal cancer can be seen in any place of the esophagus tube.

Unintentional and sudden weight loss is the very obvious symptom of esophageal cancer. A person who is losing weight without trying to lose weight should immediately consult his doctor to know what the reason is.

Difficulty or pain felt during swallowing food might also be the symptom of esophageal cancer. The throat might feel that it is pressured and might be irritated. Normally this symptom along with flu related or flu illnesses might disappear after some time but if it is a symptom of esophageal cancer it might not disappear.

When there is cancer in the esophagus the voice would become hoarse and the patient would feel better after frequent clearing of his throat. Even though hoarseness of the throat can be a symptom of various other diseases it is better to get checked.

Patients suffering from this disease might also cough persistently. Heartburns too are common. Heartburns are nothing but burning sensations or pain felt at the back of the breast bone.

Sometimes the sufferers might also feel that food has got stuck to the chest or throat. In some the esophagus becomes narrowed that the space for food to travel down the stomach is reduced considerably and hence they feel as if the food has stuck to the food pipe.

Difficulty to swallow foods and hiccups are also symptoms of esophageal cancer. When both occur simultaneously then one can be sure that it could be due to esophageal cancer.

Natural Remedies:

There are certain natural remedies that offer a promising cure for esophageal cancer. Along with the natural remedies and a well-researched different diet pattern, a few simple adjustments to your lifestyle can make a huge difference to your efforts for prolonging the life for several years. You can increase your chances of surviving esophagus cancer now by trying these proven natural remedies discussed

Immunotherapy Kill Breast Cancer Cells By Using Dc-cik Cells

Breast cancer deaths have increased by 38.91 percent. 84 percent of breast cancer patients do not attach importance to self-examination and treatment. Statistics show that breast cancer is the first female cancer. The diseases usually can despoil of young. Every one suffers various pressures from the society of increasingly severe competition. stress can actually depress the immune system and also cause an agitating mood, the endocrine disorder, which makes human body system out of balance. Many young women appear such symptoms of breast pain, breast color change, These are the performance of sub-health. Conclusion Immunologic function of early breast cancer patients does not decrease significantly, and cancer does not suppress organism immunologic function obviously. These early symptoms are often ignored, it is always early signs of breast cancer. Immune system is taken seriously more and more in the body against tumors. Immunotherapy is called the fourth cancer treatment modality for this.

Current biological therapies have demonstrated excellent efficacy in PsA and have been shown to be safe agents. Immuno biological therapy to kill residual cancer cells by using DC-CIK cells. It can improve patient survival and quality of life. If breast cancer patients get the Immuno biological therapy in time, canimprove the immune system of patients effectively, Improve patient diet and sleep and enhance the patient’s physical. It is very important to prevent recurrence and metastasis of breast cancer. Immuno biological therapy is another means to treat cancer after surgical treatment, chemotherapy and radiotherapy. It can better alleviate the side effects of chemotherapy. It can better alleviate the side effects of chemotherapy to ensure the smooth progress of chemotherapy, and makes white blood cell’s quantity to increase, and energy The enhancement white blood cell bites the fungus ability. DC and CIK are two important parts of breast cancer immune therapy. DC can identify the antigen, activate acquired Immune Deficiency Syndrome. CIK secrete Cytokines and to kill tumor cells in breast cancer. The therapy can significantly inhibit the growth of breast tumor cell, and help the body to restore immune system.

TCM is well recognized for its remarkable effectiveness in offsetting the side effect caused by the toxic and chemical treatment of cancer cases in the western medical system. The adjuvant treatment of patients with primary invasive breast cancer is beneficial. If the cancer patient get the chinese medicine for adjuvant treatment in time while doing the immuno biological therapy, significantly reduce the side effects of chemotherapy after surgery.

The Must Know For Stage 4 Cancer Cure

You don’t need a medical doctor to prescribe this natural medicine to help treat cancer. Here is a must know for a cure for stage 4 cancer or any stage of cancer. You will be astonished to know that a simple fruit like graviola tree and so called angmo durian can be a great medicine for cancer cure.

It has been found that this miracle fruit able to bring about many healing. It is effectively safe to help to treat cancer and does not cause any nausea, weight loss and loss of hair. Build up your immune system and help to prevent any further infections. Taking this fruit it will help you feel strong and healthy and a good course of treatment for your condition. Not only so, you will feel more energized and positive in your thinking and desire for life.

Now there is hope for a stage 4 cancer cure or at any stage of cancer. Based on some tests that has been performed, it has shown that the extracts from the Graviola tree can help effectively kill malignant cells in 12 types of cancer which can also help to treat problem like colon, pancreatic cancer, prostate, lung and breast cancer. It is powerful in helping to slow down the development of the cancer cells and help get rid of the cancer cells in your body.

This invention was carried out by a drug company who began a search for cancer cure that research on Graviola. The result shown its great healing properties for cancer. The Graviola leaves and stems were found to be effective in helping to attack and destroy cancer cells and the best part about this fruit is that patients does not develop any devastating side effects such as nausea and hair loss as experienced by most cancer patients.

Back in South America, the native Indians has also used various parts of the Graviola tree which include the bark, leaves, roots, fruit and fruit seed as a medicine to treat problems like heart disease, asthma, liver problems and arthritis.

If you come across someone you know who has contracted cancer or a stage 4 cancer, and is looking for natural medicine to treat cancer or a stage 4 cancer cure, you will know what to recommend to him or her now.

Cancer; One Of The Top Killing Diseases In The World

It’s sad, but very true. Variations such as prostate cancer, ovarian cancer, skin cancer, and bladder cancer have widely become “top killers” amongst people all over the world. One of the reasons for this is because of the way people eat. I know that might sound really far-fetched, but if you do a little research you soon find out that this is actually a very true fact. Fatty foods, candy, junk food, etc can possibly turn your body into an infestation of not only fat, but also some other scary diseases such as cancer.

For men, the two top diseases as far as malignant neoplasm goes is prostate and pancreatic. For women, its ovarian, skin and breast cancer. Obviously as far as skin cancer goes – this doesn’t really have much to do with your diet. But the other ones listed above very much do. It seems that a lot of people simply eat what they eat because they aren’t sure what kind of diet they should be ingesting. Thankfully for us, there are several million websites and books on this subject, however, this can become quite time consuming.

One of the best things I can suggest to you is to find a website that is specifically designed in selling natural treatments for cancer books. These are going to be books that you can buy, download and read at your own leisure. They are going to teach you things like:

– The 2 ingredient diet about which an oncologist said; “this diet is far and away the most successful anti-cancer diet in the world”. He further claimed that the inventor of the diet (a six-time Nobel Prize nominee) “demonstrated to my initial disbelief, but lately, to my complete satisfaction in my practice is: cancer is curable, the treatment is dietary/lifestyle, the response is immediate; the cancer cell is weak and vulnerable…”

– The nutritional supplement for which physicians are reporting complete remission of aggressive, stage IV cancers that have metastasized, as well as continued positive responses in other patients with previously chemo-resistant cancers. One treatment center has noted a 70% positive response rate in Stage IV cancer patients with most taking eight teaspoons of the supplement per day. One Stage IV breast cancer patient who refused chemo and radiation and was given two weeks to live by Hospice, got better with the help of this supplement. This supplement has also been shown to reduce the negative side-effects of chemotherapy and radiation.

– The unique device that is reported to reduce pain, raise energy levels, and increase survival. Apparently, many physicians are recommending it to their patients. This device increases the levels of negative ions of oxygen in the body’s fluids and tissues, exactly as Nature produces. As two-time Nobel Prize winner Dr. Otto Warburg said “Cancer cannot survive in an oxygen-rich environment”. Additionally, the device utilizes specific frequencies that may enhance your immune system and eradicate bacteria and viruses linked to your cancer.

– The gentle, inexpensive DIY treatment for when you need to carry on as normal with a 50-60% estimated success rate. This London biochemist has been trying to get authorities to check out his treatment for 20 years. It apparently knocks out the mitochondria or ‘energy centres’ in cancer cells whilst leaving normal cells unharmed. It is backed up by over 50 research papers, and apparently has succeeded for breast cancer, colon cancer, non-Hodgkin’s lymphoma, glioblastoma, pancreatic cancer, etc. A low cost source is identified for the 3 25mg tablets that need to be taken each day – working out around 60 cents a day!

From the info stated above you can see that some of these books are literally going to answer all of your questions and concerns, but they are also going to teach you step-by-step procedures and methods on how to get rid of cancer the healthy way, how to eat better, and what other methods you can use in order to keep away painful side effects that cancer can often bring to the table (depending on the disease) such as chronic pain, nausea, fatigue, dizziness, wheezing, abdominal swelling, etc.

Natural therapies ARE the way to go. And if you aren’t sure if this IS the best thing for you I have to say to you; what do you have to lose? Nothing. You only have to gain from trying new things out which may in fact either cure you or make you at least feel and look better!

Natural Ways For Women To Prevent Uterine Cancer

Protect yourself from this female cancer!
Although it gets little press, uterine-also called geometrical-cancer is the most common of all gynecologic cancer! The good news? You can dramatically reduce your risk with a few proven prevention measures….

1. Adding bran to recipes sweeps away toxins!

Whole-grain fiber, like bran and oatmeal, is so effective at whisking environmental toxins out of your body, taking in more could cut your risk of endometrial cancer by almost a third, preliminary USDA studies suggest. “fiber binds to chemicals in the digestive tract, forcing them to be excreted instead of absorbed,” explains Scottish environmental health expert Paula Billie-Hamilton, M.D., author of Toxic Overload.

The study-proven dose:

At least 15 grams of fiber daily, reports The American Journal of Clinical Nutrition.

2. Sipping vegetable juice slims your silhouette and your risk!

Slightly heavy women are twice as likely to develop endometrial cancer, and obese women have triple the risk, say reserchers at the University of North Carolina. The reason: Body fat produces uterus irritating estrogen-and as fat levels rise, estrogen production skyrockets. That’s where vegetable juice comes in: Sip it daily before every meal and according to a recent study, you’ll consume 136 fewer calories per day-enough to shed 14 pounds every year!

3. Taking the pill stops cancer from starting!

Taking oral contraceptives for at least five years cuts your endonetrial cancer risk in half, studies show-and staying on them for 12 years slashes your risk by 72 percent! “The pill shuts down ovulation and stops the monthly buildup and sloughing off of the uterine lining,” explains woman’s health specialist Hester Sounder, M.D., a clinical instructor at Philadelphia’s Temple University School of Medicine. “Preventing these dramatic risk of abnormal cells ever being formed.”

Past age 37? Don’t let that stop you! As long as you don’t smoke, you can safely take low-dose pills until menopause, doctors say.

4. Eating fruit halves your lifetime odds!

According to researchers at Loma Linda University, women who eat at least two servings of fruit daily cut their risk of female cancers-including uterine cancer-by as much as 50 percent!

On a low-carb diet? Simply choose fruits naturally lower in carbohydrates, such as pears, berries, cherries and grapefruit, suggests UCLA nutrition researcher David Heber, M.D., Ph.D, author of what Color is Your Diet?

5. Stopping at one drink keeps estrogen in check!

Women who enjoy one alcoholic drink a day are half as likely to develop uterine cancer as women who regularly sip a second glass, a recent study reveals. The problem: Alcohol boost the production of estrogen in fat cells-and researchers say high levels of this tissue-damaging hormone can increase the risk that abnormal cells will form in the uterus.

Tip pour another mug of cofee instead. Sipping three cups of this antioxidant-rich brew-even decaf-daily cuts endometrial cancer risk by 59 percent, researchers report.

6. Going on guava kick keeps cells healthy!

They look like a small, smooth skinned cross between a lemon and lime-and they have a light strawberry-lemon flavor-yet experts say each tiny guava packs 1,000 meg. Of lycopene, a cancer preventing nutrient 10 times more powerful than those found in broccoli, spinach and squash. More than 60 studies show that lycopene blocks the grouth of abnormal uterine cells-while also protecting lung, stomach and breast cells against precancerous changes.

7. Cutting back on chips cut down on carcinogens!

Love potato chips and fries? Millions of Americans do, but experts now recommend eating less of them. “They contain acrylamide, a cancer-causing substance formed whwn starchy foods are heated at very high temperatures,” explains internal medecine specialist Gina Solomon, M.D., senior research scientist at Natural Resources Defence Concil in San Francisco. In fact a 2-oz serving of chips contains at least 39 times more acrylamide than what the World Health Organization deems safe in a glass of drinking water! Delicious and safe alternatives include homemade popcorn or oven-baked fries.

6 more power foods to put on your shopping list!

Each proven to help protect against female cancers:

Brazil nuts

Brown rice

Cabbage

Edamame (soy beans)

Purple grapes

Onions
Next time you’re at a supermarket…

pick up a carton of precious omega-3-enriched eggs. Nutritional powerhouse, they each contain 350 mg.of omega-3 fatty acids compared to the 58 mg. In garden-variety eggs. And French studies show that women who consume the most omega-3s (essential fats that help body cells metabolize estrogen properly) are up to 61 percent less likely to get endometrial and female cancers than women who don’t consume omega-3-rich foods.

Ayurvedic Treatment For Cancer-cancer Symtoms

Countless experiments have done and then finally an assumption was made on the basis of Nutrient Energy and Conscious Energy. At the beginning the centre was very small as well as investment for the research and development about cancer. The most important factor was that the total commitment and positive thought for the treatment of cancer.

The achievement of DS Research Centre for the treatment of cancer patients and cancer symptoms is an exceptional. The centre having a number of inventions in the field of cancer where the treatment based of Nutrient Energy for the treatment of cancer symptoms to the treatment of the distressed people. The research has not been to its final destination and it is continued. The centre has spread its branches all over India. At present the branches are located at Varanasi, kolkata, Guwahati, Bangalore and Mumbai. There is a huge request to the scientists of this centre to open new branches all over India.

The main directorial centre is located in kolkata. The first cancer cure centre of DS Research Organization was established in city of Varanasi which is considered as a sacred city. The scientists of this centre have found the source of this treatment is based on Nutrient Energy. This energy is taken by more than one thousand patients and the outcome is that they are presently leading a normal healthy life.

After the research and development activities of 45 years about cancer the fact is proved that Nutrient power based upon olden Ayurveda is very much reliable source of medicine. This invention is a step forward for the cure of cancer. The treatment can increase the life period and the quality of life of many cancer affected persons. There are also numerous patients who are completely cured and they do not take the medicine and leading a normal life as other peoples do.
The process of the treatment has been gradually developed over the years to make it more effective. DS Research Centre is able to provide the best Ayutvedic cure to the patients.

The scientists of DS Research Organization found that to be healthy in normal life with strong resistation for adverse situation, the nature has gifted us the medicine of Nutrient Energy and the various natural food is the pull of that energy.
The Bangalore centre has step forward with the success stories in cancer treatment for one year. The old treatment about cancer based on nutrient energy which is derived from human consumable is now showing a great achievement within a year. Cancer patients found a new meaning of life here.

d Mammography – The Ideal Diagnostic Process for Detecting Breast Cancer

The number of instances of breast cancer in women is increasing at an alarming rate all over the world. Although many diagnostic facilities and preventive measures are available, the awareness for the disease is not adequate and hence the disease continues to grow without any check on its increase. Although abnormal growth of breasts is considered normal in most cases it is very difficult to diagnose it as cancer with the aid of further diagnosis. 3D mammography is the latest diagnostic process for detecting breast cancer that functions with the help of low energy X rays. The objective of a mammography scan is to detect the presence of abnormal growth or ailment in the breasts through analysis of the tissues. Mammography scans use 30kVp X rays, which is considered safe and ideal for detecting the presence or symptoms of the disease.

The process of 3D mammography

The images of the breast tissues are taken on an x ray sheet. The process of capturing these images is known as mammogram. These mammograms are further developed with the aid of ionization for further analysis. They are then analysed and interpreted by radiologists who issue statements and scan reports for the use of doctors. These x rays are taken using x rays that are less potent than normal x rays used for the scanning of bones. The various types of mammography scans are ultrasound scanning, digital mammography, positron emission mammography, 3D mammography, magnetic resonance imaging and dictograph. These techniques are largely used for getting affirming results of the previous tests of mammography for deeper analysis.

Advanced scanning procedures

Ultrasound scans are resorted then normal mammography scans do not provide accurate or precise reports. Alternatively, ductography scans are also used for checking bloody discharges from nipples, which gives idea about the presence of breast cancer. Patients are also scanned using MRI scan equipment before their operations in order to evaluate the results before and after the surgery. Tomosynthesis is the latest innovation in the scanning field, which is gaining more reputation for its accurate results than any other tests present today.

Risks associated with 3D mammography scanning

The prime risk of these scans is the possible occurrence of radiation induced cancer. It is quite possible for women below the age of thirty five to be affected with radiation induced cancer more quickly than natural sources. Hence, as a precaution 3D mammography is not prescribed for women under the age of forty. As an alternative, other scanning procedures like ultrasound scanning and MRI imaging are used to get the desired results for diagnosis. However, on exceptional cases where the extent of the symptoms is severe the radiologist may recommend for mammography even when other procedures provide accurate results. It is also possible for scan procedures to miss out on detecting the existence of symptoms. It is quite difficult to detect the present due to thick tissues and inactive cancer lesions that forms in the central location of the breast, which cannot be diagnosed through normal mammography. Hence, the report may possibly give a negative report of the existence or symptom of breast cancer.

However, there is also a possibility for women to undergo repeated scanning in case false positive results were given during the tests. False positive results are when the test results declare the presence of symptoms f the cancer when actually the patient is free of any infection. It can happen due to the wrong diagnosis of the radiologist or incorrect evaluation by the doctor. Calibration issues with the equipments can also lead to incorrect results. Hence, it is advised to seek the services of a reputed diagnostic organization that has sufficient experience and provides the best results in a timely manner.

Advantages of 3D mammography

The advantages of mammography scanning are many and varied. They aid in early detection of symptoms and possible existence of breast cancer. Small and tiny tumors can also be identified with the help of 3D mammography. High risk lesions, which are otherwise unnoticed under normal mammography scanning can also, be diagnosed with the aid of these scanning techniques. The patient can be saved from the difficulty of undergoing chemotherapy in case the cancer becomes acute. Cancer is curable and is also possible to be prevented if it is diagnosed in advance. Mammography helps in reducing the possible related risks of breast cancer. It is estimated that these scanning techniques have saved at least ninety five percent of the individuals who were diagnosed of the disease.

The writer is an expert in the field of Diagnostic Services with focus on 3d Mammography & Digital Mammography .

Eerie County Reaches Asbestos Cancer Settlement

A $1.2 million asbestos cancer settlement was recently reached in Eerie County, New York regarding the ongoing asbestos cancer problems in the community.

The suit was filed by the county against several asbestos manufacturers and was finally settled after several years. Asbestos Cancer Exposure at Companies

Celotex and Carey Canada were named as the primary defendants in the case.

The suit began several years ago when Dennis Gorski was still serving as the county executive in Eerie.

Since this time he has stepped down from the position but the suit has still gone forward with the help of other county officials and residents. Accusations Made in Asbestos Lawsuit

Both companies were accused of injury and property damage due to the presence of asbestos in their building materials.

As a result of the asbestos cancer lawsuit, which was filed in 1990, the companies filed for Chapter 11 bankruptcy. Other Asbestos Suits Filed

The suit filed by Eerie County is reportedly just one of thousands that have been filed against the companies for asbestos cancer exposure.

The county received $1.2 million in the settlement but county officials claim this may not be enough to cover the cost of asbestos removals.

(Source: www.mesotheliomatreatmentcenters.org)

Do you believe you’ve been exposed to asbestos cancer? Please contact mesothelioma treatment centers to speak with someone about the resources available to you.

European Cancer Congress , Molmed Sarcoma, New Data On Ngr-htnf

MolMed, new data presented at the European Cancer Congress show a statistically significant increase in survival of patients suffering from soft tissue sarcomas treated with NGR-hTNF.

MolMed S.p.A. (MLM.MI) presented at the European Cancer Congress 2013 (ECCO-ESMO-ESTRO), in Amsterdam (The Netherlands), additional data from an ongoing randomized Phase II study evaluating safety and efficacy of its investigational drug NGR-hTNF on patients suffering from soft tissue sarcomas. Data show the impact of the weekly administration of NGR-hTNF at low doses (0,8g/sqm) in combination with doxorubicin.

Presentation: NGR-hTNF given at low dose or high dose with or without doxorubicin in soft-tissue sarcomas

The new data highlighted a statistically significant doubling of the median survival associated to a favourable tolerability profile. Of particular interest is the evidence that efficacy and tolerability were similar both in patients untreated or resistant to prior treatments.

Claudio Bordignon, Chairman and CEO of MolMed, commented: These additional results from a randomised Phase II study are relevant for two reasons: on the one hand they confirm the previously observed effectiveness of NGR-hTNF in various cancer indications; on the other hand they validate the choice of the weekly schedule of low doses administration, as already demonstrated in the treatment of malignant pleural mesothelioma, currently in Phase III clinical trial.

Randomized Phase II study of NGR-hTNF in soft tissue sarcomas

This four-arm trial was designed to select the best NGR-hTNF regimen for patients with sarcomas. The primary aim of achieving a doubled three-month progression-free rate (40% vs 20%) was met by the combination of low-dose intensified NGR-hTNF (0.8 g/sqm weekly) with doxorubicin, after both the first and the second trial stages.

Preliminary data presented in June at the 49th annual meeting of the American Society of Clinical Oncology (ASCO) also show that the superiority of this regimen over the other ones in terms of progression-free survival (with a three-fold increased median duration) translated into an analogous advantage in terms of overall survival (with a two-fold increased median time).

About NGR-hTNF

NGR-hTNF is a novel therapeutic agent for solid tumours which displays antitumor activity through its specific binding to blood vessels feeding the tumour mass. NGR-hTNF is being investigated in a large clinical program, including Phase II trials in six indications: colorectal, lung (small-cell and non-small-cell), liver and ovarian cancer, and soft tissue sarcomas and a pivotal Phase III trial in malignant pleural mesothelioma: based on the trial follow-up evolution, results are now expected to be available between December 2013 and January 2014.

About MolMed
MolMed S.p.A. is a biotechnology company focused on research, development and clinical validation of novel anticancer therapies. MolMeds pipeline includes two antitumour therapeutics in clinical development: TK, a cell-based therapy enabling bone marrow transplants from partially compatible donors, in absence of post-transplant immune-suppression, in Phase III in high-risk acute leukaemia; NGR-hTNF, a novel vascular targeting agent, in Phase III in malignant pleural mesothelioma and in Phase II in six more indications: colorectal, lung (small-cell and non-small-cell), liver and ovarian cancer, and soft tissue sarcomas. MolMed also offers top-level expertise in cell and gene therapy to third parties to develop, conduct and validate projects from preclinical to Phase III trials, including scale-up and cGMP production of clinical-grade viral vectors, and manufacturing of patient-specific genetically engineered cells.MolMed is headquartered at the San Raffaele Biomedical Science Park in Milan, Italy. The Companys shares are listed on the main market (MTA) of the Milan Stock Exchange. (Ticker Reuters: MLMD.MI)

FONTE: MolMed.com